There's going to be a very dramatic shakeup for MiLB. MiLB will be reduced to only 120 teams. MLB is going to take ownership of all the teams. AAA teams will most likely be within driving distance to the MLB franchises. Affiliations will be moved around dramatically.
I believe there is already substantial traction for a Nashville team (currently AAA). Other team: San Antonio/Vancouver/Charlotte
The league, which last expanded in 1998, has some tidying up to do, but for Commissioner Rob Manfred, he envisions a team in the Pacific and Eastern time zones. “Baseball is a growth industry,” Manfred said. “Eventually, we’d like to get to 32 teams.”
Maybe: Portland/Vancouver and Nashville (I know they aren't EST)?